Alternatives & Traditional

Posts tagged ‘antioxidant’

Top 5 Worst Internet Health Information Sites: Curezone.org Part 2: Alkaline/Acid Support Forum Part 2

Acids erroneously get a bad rap from sites trying to promote the alkalize for health myth. Acids are actually essential not only to our survival, but also our existence.  These essential acids include hydrochloric acid, pyruvic acid, acetic acid, carbonic acid, hyaluronic acid, glucuronic acid, malic acid, lactic acid, citric acid, uric acid, fatty acids, amino acids, ascorbic acid, pantothenic acid, folic acid, etc.

Acids generated by the body for health include:

  • Stomach acid for the digestion of proteins and to kill ingested pathogens.
  • Lactic, acetic and other flora generated fatty are needed for proper mineral absorption.
  • The same acids listed above also kill off pathogens.
  • Hyaluronic acid helps to prevent the spread of pathogens, cancer cells and venoms.
  • Hyaluronic acid also holds our cellular matrix together.
  • Flora generated fatty acids keep Candida growth under control and to keep Candida from morphing in to its pathogenic fungal form.
  • Glucuronic acid aids in detoxification of the body.
  • As building blocks for all cells, hormones, neurotransmitters, antibodies, etc.
  • Amino acids are needed the production of adenosine triphosphate (ATP), which fuels the cells and helps them to function properly.
  • Carbonic acid regulates blood pressure, is also required for the production of stomach acid and coverts highly toxic ammonia in to the antioxidant uric acid.
  • Citric acid is produced by bone cells to maintain healthy bones through bone remodeling.
  • Citric, malic and pyruvic acids are required form the formation of adenosine triphosphate that fuels our cells and helps them to function properly.

These are just some of the acids generated by the body to benefit the body.

The body also relies on external source of acids for health.  For example, one of the most common antioxidants in plants is the polyphenol tannic acid. Chaparral contains nordihydroguaiaretic acid (NDGA), the strongest natural antioxidant known.  Not only does NDGA work in both the lipid and water portions of cells unlike most antioxidants, NDGA has also been found to significantly inhibit cancer cells.  Chlorogenic acid and betulinic acid are powerful anti-viral and anti-cancer compounds.  Usinic acid is a strong antiseptic found in usnea lichen and kombucha tea. Benzoic acid is another strong antiseptic found in various plants. Amino acids not synthesized by the body must be obtained from external sources.  Same with fatty acids that serve various functions from killing pathogens to building cell membranes. Various vitamins required by the body such as vitamin C and B5 are acids. Orthosilicic acid derived from external sources and created with the help of stomach acid forms various tissues in the body.  These include bone, cartilage, skin, tendons, ligaments, teeth, etc.  Salicylic acid is a common anti-inflammatory found in a number of plants.

Ironically, the alkalize or die supporters are big fans of diets high in fruits and vegetables for health.  And what are some of the acids found in fruits and vegetables?  Oxalic acid, malic acid, citric acid, chlorogenic acid, succinic acid, fumaric acid, lactic acid, oxalacetic acid, tartaric acid, quinic acid, benzoic acid, acetic acid, allantoic acid, sulfuric acid, phosphoric acid…………

Speaking of diet, the alkaline supporters rely heavily on what they refer to as alkalizing foods.  Various lists of acid forming and alkaline forming foods can be found on the Internet, but they rarely match up.  Not surprising since there is not any solid science behind the claims.

For instance, one website shows various soy products as being highly alkaline, while another site claims soy is an acid forming food.  These same sites also disagree on white kidney beans with one site claiming they are acidic and the other alkaline.  Several sites I found claim avocado is alkaline and one claims it is acidic.  Looking at other sites I found one that claims honey is highly acidic and another site claiming honey is alkaline.  One site claims all forms of rice are acidic and another site claiming japonica and wild rice are alkaline. Blueberries are considered acidic on some sites and alkaline on other sites.  Depending on the site cow’s milk is considered alkaline, neutral or acidic regardless if raw or pasteurized. There are plenty more contradictions between the various sites.

I see a lot of the confusion being that there is no basis for the claims of acid or alkaline forming.  Sugar is considered acid forming even though the fruits and vegetables considered either acid or alkaline all contain the same sugars.  And fructose found in so many fruits that are considered alkaline is processed the same way as the fructose found in “junk foods” they consider acidic. Foods high in acids, such as lemon and kale are considered alkaline, while other acid sources such as pomegranates and cranberries are considered acidic.

There just does not seem to be any rational for the foods are either acidic or alkaline claims.  Foods high in protein you would think are acidic due to the breakdown of proteins results in highly alkaline ammonia first, which then forms uric acid.  Yet, spirulina which is nearly 4 times higher in protein than beef, which should be considered acidic is actually considered alkaline. Could it be based on fiber content?  Can’t be.  Jerusalem artichoke is considered acidic and sweet potatoes are considered alkaline despite both being high in fiber.  Could it be the starch content?  Again, not the case.  Yams, which are considered alkaline are nearly twice as high in starch than lentils that are considered acidic.  Maybe it is the simple sugar content.  Yet grapes, which are loaded with sugar are considered alkaline while Brussel sprouts, which are lower in sugar are considered acidic.  Maybe it is the mineral content.  Since there are so many different minerals I will just focus on the three that would be considered the primary alkaline minerals potassium, calcium and magnesium.  Blackberries, which are considered acidic are significantly higher in all three minerals than cantaloupe that is considered alkaline.

Milk regardless if raw or pasteurized still contains the same amount of protein, sugar and minerals.  Yet some people claim that raw milk is alkaline while pasteurized milk is acidic as where other people claim all forms of cow’s milk are either acidic, neutral or alkaline.

Beef is considered acidic even though it is high in “alkaline minerals” such as potassium, sodium, calcium and magnesium.

I have also seen lists claims that vinegar or kombucha tea are alkaline, even though there have been reports of people developing acidosis after consuming too much of these acid sources.

Lemon juice though, which also contains sugar and various acids is actually considered alkaline.  The actual pH of lemon juice is actually acidic, but as with every food and drink we ingest it stimulates an alkaline effect in the body.  How can this be?  Simple.  When we ingest foods or drinks the stomach acidity has to drop in pH to a certain level of acidity before the stomach can empty in to the intestines.  Therefore, it does not really matter what proteins, minerals, sugars, etc. that are in the food or drink.  They all leave the stomach at the same acidic pH range.

The stomach contents dumped in the intestines, known as chyme, is always acidic.  The intestines cannot handle this kind of acidity though.  Therefore, as soon as the chyme enters the first part of the intestine it is met with alkalizing sodium bicarbonate released by the pancreas.  Interestingly, the alkaline sodium bicarbonate is formed from sodium chloride salt that the alkaline supporters consider acidic.

From there the byproducts of the food can be dealt with in different ways.  Sugars for example are considered acid forming. So what is the acid byproduct of sugar metabolism?  Carbon dioxide. Is carbonic acid acidifying or alkalizing though?  Actually both.

Carbon dioxide combines with water to form carbonic acid.  Carbonic acid serves several beneficial functions for the body such as regulating blood pressure.

If a person hyperventilates this will cause the person’s blood to become excessively alkaline.  As a result the blood vessels constrict pushing blood away from the brain causing the person to pass out.  When the person passes out they fall down, which helps in part to restore blood flow to the brain.  Respiration also slows down or temporarily stops in part to increase carbonic acid levels back to normal.  This allows the blood vessels to relax restoring blood flow to the brain.

Another function of carbon dioxide is the formation of sodium bicarbonate.  The sodium is provided by sodium salt we ingest.  This sodium bicarbonate functions to neutralize the acidity of chyme as it leaves the stomach to protect the intestines from the acidity.

As proteins are broken down the amino acids that make them up are released.  Amino acids are based with ammonia, which is not only highly alkaline, but also highly poisonous to the body.  Carbonic acid helps convert the highly toxic ammonia in to uric acid.  Uric acid is one of the body’s primary antioxidants.  Because an acid is being used to covert the toxic ammonia in to another acid there is no real gain in acidity.

Carbonic acid is also required for the formation of stomach acid, which among other functions helps with the absorption of minerals needed to build bone.

Excess carbon dioxide is eliminated so that the proper pH of the blood is maintained.

As we can see it does not matter what the food is the results are all the same.  Food is first brought to an acidic pH then the acidity is neutralized as it leaves the stomach.  The only way a food can alter the body’s pH to make it either acidic or alkaline is for that food to overwhelm the body’s natural pH buffers.  This is extremely difficult to do unless consuming extremely large amounts of acid sources like vinegar or alkaline substances like calcium carbonate.

The only foods that do not have their pH altered by the stomach acid or the bicarbonate released on the chyme are fibers.  Fibers are not really food for the body though, but rather the flora.  The beneficial acid producing flora that inhabit various parts of our body enzymatically break down fibers, which are long chain sugar molecules, in to simple sugars to feed on.  The bacterial fermentation of these sugars allow the bacteria to produce acids that control pathogen overgrowth and aid in mineral absorption.

Now we can see why the acid food and alkaline food claims contradict each other.  They are not based on any real facts, but rather opinions.

Even if the blood starts to become acidic the primary means of pH for the body is respiration.  Therefore, as blood acidity increases so does the respiratory rate to increase alkalinity by decreasing carbonic acid and hydrogen ions.  On the other hand if someone goes in to alkalosis their respiratory rate will decrease or temporarily stop to allow the buildup of carbonic acid and hydrogen ions to restore the pH.

If the pH goes beyond the range that respiration alone can handle then the body can use other means to maintain it’s pH.  Kidneys are second in line for maintaining pH.  Kidneys do this primarily by retaining or excreting hydrogen ions and bicarbonate to raise or lower pH.

Respiration and kidney function account for virtually all the pH regulation in the body.  Since neither contain “alkaline reserves” there is no depletion of “alkaline reserves” as is often claimed by the alkaline diet myth supporters.

Of course primary pH regulation is more involved, but I am trying to give a very basic expiation for people.  If you want a more detailed explanation of respiratory pH regulation here is some suggested reading with a more involved but still simple to follow explanation:

http://www.biology.arizona.edu/biochemistry/problem_sets/medph/02t.html

Some people claim that acid foods deplete the bones of minerals because the bone minerals are used to buffer the acids.  This is even more rare than acidosis itself since buffering of blood acids with bone minerals is the last resort used by the body to maintain pH.  Again respiration is the body’s main means of pH regulation followed by hydrogen ion retention or elimination by the kidneys.  These account for virtually all the pH regulation of blood.  The body also uses protein buffers, such as albumin, and phosphate buffers to regulate blood pH long before using bone minerals.  Therefore, acidosis would have to be extreme and long term before the acidosis would have any effect on the bones.  In acidosis this extreme the worry would not be bone loss, but simply survival since severe acidosis can be deadly.  Luckily acidosis this extreme is so rare that a person would likely have a better chance of being struck by lightening multiple times than to develop acidosis this severe.

There are some foods that are considered acidic such as beef, dairy and colas that can induce bone loss.  This process though has NOTHING to do with acidity.  These are all high phosphorus sources, which is what leads to the bone loss.  Phosphorus is essential to an extent to maintain healthy bones, but in excess it leads to bone loss by triggering a process known as pseudohyperparathyroidism (PHPT).  This is similar to another condition known as hyperparathyroidism (HPT).  In both cases the parathyroid glands release a hormone known as parathyroid hormone (PTH), which breaks bone tissue down raising serum calcium levels.  There are several causes of this.  Parathyroid nodules, which are believed to be triggered by a lack of vitamin D can increase PTH output.  PTH is also released in response to either actual serum calcium deficiencies, such as from insufficient vitamin D levels, or perceived low serum calcium levels.  The release of PTH due to perceived low serum calcium is known as PHPT.  When people consume foods high in phosphorus an imbalance can occur between calcium and phosphorus levels with a major increase in the phosphorus ratio.  The parathyroid glands respond to this perceived drop in calcium by releasing PTH, which raises calcium levels to restore balance of the calcium-phosphorus ratio.  Again, this has absolutely nothing to do with these foods being acidic.

Milk does contain a large amount of calcium, but it still induces PHPT for a simple reason.  Protein in milk blocks calcium absorption, but not phosphorus absorption.  Protein’s blocking action on calcium absorption is also evidenced by the myth that milk creates mucus, which I addressed in this video:

http://www.youtube.com/watch?v=DUCgEL7JaOI

It is also evidenced by the fact that the two nations with the highest consumption of dairy in the world, the United States and Finland also have the highest rates of bone mineralization diseases in the world.

Another common misconception promoted heavily on alkaline promoting sites is that pH strips can be used to monitor blood pH by testing the pH of either the urine or the saliva. Salivary and urinary pH though do not reflect the actual pH.  The pH of both can change for a number of reasons without changes in the blood pH.

Urinary pH for example can change depending on the amount of urine hydration there is or the amount of minerals being excreted through the urine.  Some medications can also alter urinary pH.  Bacterial infections can split urea to produce highly alkaline ammonia to protect themselves from acidity.  In this process urinary pH rises (becomes alkaline) from the infection despite no changes to the blood pH.

Salivary pH increases as we sleep since saliva production shuts down.  Saliva helps to alkalize the mouth and wash away acid forming bacteria in the mouth.  Therefore,  when we sleep the bacteria levels go up, also resulting in “morning breath”, causing a lower (acidic) pH in the mouth.  As we wake up and become more active saliva helps to wash away some of the bacteria and brings the pH of the mouth back up.  Dry mouth from methamphetamine use, certain medications like antihistamines or certain diseases such as Sjogren’s syndrome can also lower the salivary pH.  Other factors that can affect salivary pH include whether or not you just brushed your teeth or what you recently ate or drank.  It has also been known for decades that something as simple as thinking about a certain food can alter salivary pH as the pH of the saliva adjusts in anticipation of the food.

This is why the only way you will know what your blood pH is would be through a blood test.  And even that can change in an instant.  For example, as I have pointed out a number of times respiration is the body’s primary method of pH control.  Hyperventilating will alkalize the body quickly, but you will also pass out due to the induced alkalosis.

This is an example of why I encourage people to learn how the body really works instead of accepting all the hype out there on the internet or in books, magazines, etc.  I recall when the book Alkalize or Die book came out.  And of course many people simply accepted the claims as fact without bothering to check other sources to see if this author’s opinion were fact.

I know scare tactics help to sell books, but still we are talking about people’s health and people are profiting off this nonsense they promote while putting people’s health at risk.  Just because something is in print this does not make it automatically true.

Advertisements

Ozone Misinformation

I was recently reading a post on the internet entitled “Ozone Therapy/ Common Mistakesposted by Bret Peirce, founder of American Cancer Advocates.

Even though the concept of the article is good, most of the information is incorrect.

Ozone therapy is fantastic for many things and administered properly is one of the safest therapies available for many diseases and disorders including cancer.  As with any therapy though, ozone therapy can be very dangerous and cause a lot of harm and possibly even death if improperly administered.  Therefore, the goal of this blog article is to address what I see as misinforming claims being made by Mr. Peirce regarding ozone therapy.

Mr. Peirce starts by stating he is listing the primary mistakes made with ozone therapy in regards to cancer.

In the first claim Mr. Peirce states a failure to check lactic acid levels before starting the therapy.  The problem with this claim is that contrary to popular belief cancer cells DO NOT secrete lactic acid.  In fact, no human cells secrete lactic acid.  The only cells in or on the body that secrete lactic acid are beneficial bacterial cells that inhabit the body commonly referred to as “flora”.  These bacteria secrete lactic and other acids to help control pathogens and to aid in nutrient assimilation.

Human cells can generate non-acidic lactate, which is frequently and incorrectly referred to as lactic acid even though lactic acid and lactate are not the same thing.

Regardless, lactate is an important fuel for the body’s cells and is generally regulated by the body preventing excessively high or low levels.

Reading Mr. Peirce’s past posts Mr. Peirce’s reasoning is that oxygen cannot enter cancer cells unless the cells are sufficiently alkalized. Therefore, Mr. Peirce recommends using heavy metal salts to neutralize the lactic acid so oxygen from oxygen therapies can enter the cancer cells.  The problems with these claims are:

  1.  Cancer cells do not secrete lactic acid.
  2. The internal pH of cancer cells is already more alkaline than healthy cells and excess alkalinity of healthy cells have been shown to induce transformation of healthy cells in to cancer cells (1,2,3,4,5,6).  Cancer cells cannot tolerate an acidic pH, which kills them, and therefore cancer cells export acidic hydrogen ions (protons) in to the external matrix to maintain the internal alkalinity cancer cells need to survive and proliferate (5,6,7,8).
  3. Alkalinity actually promotes anaerobic glycolysis of cancer cells (9).  This could be from the fact that alkalinity reduces oxygen utilization by inhibiting oxygen release from hemoglobin and by constricting blood vessels leading to decreased circulation(10,11,12).
  4. Cancer cells have a higher affinity for oxygen than normal cells and utilize that oxygen very well (13,14).  On the other hand cancer cells die in the absence of oxygen.  The process of cancer cells dying due to a lack of oxygen during their early stages of development lead to the production of angiogenesis growth factors that stimulate the formation of blood vessels that brings sufficient oxygen and nutrients to the cancer cells for the cancer cells to survive and thrive (13,15,16).

Therefore, adding heavy metal alkaline salts as is being recommended will make no difference as regards to the effectiveness of ozone therapy, but the salts can pose health problems themselves.

For example, the most common alkaline salt recommended for cancer treatment alone or with ozone is cesium chloride.  The use of cesium chloride is actually based on numerous false premises, but that is another story.  Cesium chloride has not only been shown to be a failure in the treatment of cancer, it has also been shown to induce cancer and promote existing cancers (17,18,19,20,21,22,23).

Cesium chloride can also cause heart related side effects (24,25,26,27,28,29,30,31,32,33,34) and liver damage (35).

In Mr. Peirce’s second claim Mr. Peirce claims it is a mistake to fail using a maximum dose.  Not only is this claim incorrect, but it is EXTREMELY dangerous!

First of all there is no definition of “dose”.  Dose could refer to the concentration or the volume, which both present their problems in excess.

Concentration refers to the milligrams per milliliter (mg/ml) also referred to as gamma.  Since most ozone therapy for cancer is administered internally through injection or insufflation the proper concentration is essential.  Ozone is administered internally only in trace amounts of ozone to oxygen since higher concentrations can damage tissues and hemolyze red blood cells leading to serious health issues.

Volume refers the actual amount of ozone administered at a given concentration.  If ozone is administered at the proper concentration then larger volumes can be administered as long as it is administered slow enough.  Administering a large volume of ozone to quickly by injection or vaginal insufflations risks the possibility of embolus.  Administering ozone too quickly though by rectal insufflation risks overinflating the colon and rupturing the colon wall.

Mr. Peirce’s claims continue with oxidative stress can be countered by adding catalase. And if no oxidative stress is present the person can go higher in their dose.

If the author had done his research he would have found that catalase (CAT) is only one of several antioxidant enzymes produced by the body.  And CAT along with superoxide dismutase (SOD) and peroxidases are increased by properly administered ozone therapy.  This reduces the risk of oxidative damage to healthy cells already, but a high concentration or dose of ozone too quickly can still cause damage or death regardless of the increase of antioxidant enzymes stimulated by ozone therapy.

Pathogens and cancer cells lack these defenses.  This is why cancer cells and pathogens are  selectively destroyed by properly administered ozone therapy without destruction to healthy tissue.

Excessive concentrations of ozone though can overwhelm the body’s antioxidant enzyme systems though leading to tissue destruction.  As mentioned earlier this is why the recommendation of maximizing ozone dosing is not only incorrect, but also dangerous.

It also needs to be kept in mind that the antioxidant enzymes taken as a supplement may be destroyed long before they could be absorbed unless they are enteric coated.

Since many people use ozone therapy personally at home there would not be a way for them to monitor the oxidative stress on red blood cells.  Even in a clinical setting where blood samples can be monitored for oxidative stress by the time the red blood cells are hemolyzed it is too late.  Therefore it is essential to use the proper concentration of ozone used in guidelines for ozone therapy set by over a hundred years of proper research and not just go for a “maximum ozone dosing” as recommended by Mr. Peirce.

Another issue with high dose ozone being overlooked by Mr. Peirce is that rapid destruction of cancer cells can not only lead to tissue damage, but also potentially kill the patient.  There are several reasons for this:

-The destruction of cancer cells leads to the formation of uric acid.  A sudden high uric acid load can lead to kidney damage as these sharp crystals get excreted through the kidneys where they can cut up the kidney tissue.  Other tissues in the local region of the destroyed tumor can also be damaged from the elevated uric acid.  This is especially dangerous in the case of brain tumors as the uric acid can inflame the brain tissue leading to dangerous brain swelling.  Since the brain is inside an inflexible skull there is no room for the expansion and the brain can suffer crushing damage if the brain swells too much within the skull.  To reduce these risks the cancer cells must be killed off little by little to allow time for clearance of the uric acid.  Drinking plenty of water throughout the day when using ozone therapy to help hydrolyze the uric acid in to safer urea can also help.

High dose ozone can further increase uric acid levels by hemolyzing red blood cells.  Hemolysis though does not occur when proper ozone levels are used, which are actually quite dilute when administered internally.

-The destruction of cancer cells leads to an increase of alkaline potassium released from the cancer cells as they are destroyed.  A sudden surge of potassium can create electrolyte imbalances that can impair heart function if cancer cells are destroyed too rapidly by higher than recommended ozone levels.

-In cases of brain tumors there is also danger of swelling if cancer cells are destroyed too quickly not only due to uric acid induced inflammation, but also due to the release of serum from dead cancer cells and the surge in potassium that can draw water in to the tissues by osmosis.  Again, this can be avoided by slowly destroying the cancer cells with the dilute doses of ozone used with internal ozone therapy rather than the dangerous “maximum ozone dosing” recommended by Mr. Peirce.

-The other risk is a dangerous infection condition known as sepsis.  Large tumors can be destroyed very easily with high dose ozone, but this is not a safe thing to do.  Dead cancer cells constitute infectious material to the body just like any other dead tissue in the body.  Of a person had a malignant tumor the size of a basketball it could be easily destroyed with a single ozone treatment using high concentrations of ozone. But the massive amount of dead cellular debris would kill the patient from sepsis.  Again, ozone therapy needs to be used in low concentrations, not “maximum ozone dosing”, to gradually kill the cancer cells.  And it is essential to allow time between treatments for the body to clear the dead cellular debris as well as the uric acid, and to allow time for the electrolytes to rebalance.  Using a shotgun approach of “maximum ozone dosing” could kill the patient.

Mr. Peirce then repeats the myth that alkaline salts are required to allow oxygen to enter the cancer cells.  This claim is based on the myth that cancer cells are totally anaerobic.  Cancer cells though are only partially anaerobic with the majority of energy for cancer cells being produced by an aerobic processes known as oxidative phosphorylation (OxPhos).  In other words, oxygen not only readily enters cancer cells, but cancer cells are highly reliant on oxygen for energy production.  A low pH does not interfere with this process as Mr. Peirce claims.

Interestingly, Mr. Pierce later contradicts himself by admitting “hormone dependent cancers, sarcomas, and advanced cancers can also burn glucose oxidatively”.  This would be impossible if oxygen could not get in to cancer cells without alkaline salts as Mr. Pierce claimed previously.

Additionally, it is not only hormone dependent, sarcomas and advanced cancers that burn glucose oxidatively.  All malignant tumors including cancers in their earliest stages primarily burn glucose through OxPhos as studies have shown (13,14).

Next on Mr. Peirce’s list is an application failure.  In this case Mr. Peirce states “it is a mistake to not use ozone in high enough concentrations as well as causing irritation to the tissues or not using a humidifier”.

As previously mentioned though high concentrations of ozone are contradicted in internal ozone therapy due to the fact that high concentrations of ozone will damage the tissues and destroy red blood cells.  In addition, as pointed out in cases of cancer high concentrations of ozone can lead to tissue damage and possibly death.  The correct concentration of ozone used in internal therapies is  highly dilute, not concentrated as Mr. Peirce advises.  The recommended concentration of ozone for internal therapy is only around 0.1% ozone and 99.9% oxygen to prevent tissue damage and hemolysis.

This brings up another of Mr. Peirce’s contradictions.  Mr. Peirce keeps recommending high concentrations of ozone, which will cause tissue irritation and damage while at the same time claiming it is a mistake to cause tissue irritation with ozone.

The use of a humidifier in ozone therapy is controversial.  The humidification will result in a loss of some of the ozone as the ozone reacts with the moisture to form peroxides.  This may be helpful in the sense of reducing the damage that could occur from improperly using high concentrations of ozone.  Although, this also means that the person will not be able to properly gauge the level of ozone being administered for safety and effectiveness.  Imagine if your pharmacist was diluting down your medications with a random amount of water then telling you to take the same dose as would be normally recommended.  That would be ridiculous, yet this is the same principle as using a humidifier with ozone.  This is one of the reasons I don’t use humidifiers with ozone.  The second reason is because the mucus membranes and blood are already moist.  Therefore, if proper low concentrations of ozone are given in the first place the required moisture for oxidation will already be present in sufficient levels.

Another dangerous claim made by Mr. Peirce is at the end of his paragraph discussing inhaling ozone.  Mr. Peirce is correct that inhaling ozone is an irritant.  Mr. Peirce goes on to say though that inhaling ozone must be done at a lower concentration through a humidifier.  He also recommends doing slight exercise during the therapy and running the oxygen through the ozone generator at up to 6 liters per minute.  And finally Mr. Peirce states if the ozone causes a cough or irritation despite the humidifier to slow down the oxygen rate.  So what are the problems with these claims?

Well, first of all it is not recommended to inhale ozone for several reasons.  The lungs are more sensitive to ozone than other tissues and can be easily damaged by high levels of ozone.  In addition, ozone can trigger asthma attacks in those prone to asthma.

The most dangerous part of Mr. Peirce’s claim is that if a cough or irritation develops that you should slow down the oxygen rate.  The problem with doing this  is that this will significantly INCREASE the concentration of ozone increasing the risk of serious damage.  Ozone concentration is regulated by several factors such as voltage and discharge tube length.  The third factor is the flow rate of oxygen. The faster the flow rate the less contact time the oxygen has in the discharge tube and thus the lower the ozone concentration.  When you slow down the flow rate as Mr. Perice dangerously advises there is a greater contact time of the oxygen in the discharge tube, which increases the concentration of ozone. If you are developing a cough or irritation from the ozone concentration as it is showing damage occurring then why would anyone recommend increasing the concentration dangerously higher?!!!

Another issue not even mentioned by Mr. Peirce is that there are different methods of generating ozone and not all ozone units can utilize oxygen as a starter gas.  Using air with ultraviolet or hot corona systems also present a problem of the generation of nitrogen and sulfur based acids that can irritate or burn the tissues in the presence of moisture.

Anyone considering ozone therapy should research the subject thoroughly before initiating the therapy.  Thoroughly researching the subject is also recommended even if receiving ozone from a practitioner to make sure they understand the therapy and are administering the therapy properly for the particular condition.
Select References:

  1. Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEBJ 2000 Nov;14(14):2185-97
  2. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc Natl Acad Sci USA 1990 October; 87(19): 7414–7418
  3. 31P NMR analysis of intracellular pH of Swiss Mouse 3T3 cells: effects of extracellular Na+ and K+ and mitogenic stimulation. J Membr Biol 1986;94(1):55-64
  4. Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+. J Cell Biol 1984 Mar;98(3):1082-9
  5. Vacuolar H(+)-ATPase in Cancer Cells: Structure and Function. Atlas of Genetics and Cytogenetics in Oncology and Haematology       Sept. 2011
  6. Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity. Am J Physiol Cell Physiol 286: C1443–C1452, 2004
  7.  Targeting vacuolar H+-ATPases as a new strategy against cancer. Cancer Res 2007 Nov 15;67(22):10627-30
  8.  Vacuolar H(+)-ATPase signaling pathway in cancer. Curr Protein Pept Sci 2012 Mar;13(2):152-63
  9. Role of the Intracellular pH in the Metabolic Switch Between Oxidative Phosphorylaiton and Aerobic Glycolysis-Relavance to Cancer.  Cancer 2011;2(3):WMC001716
  10. Biochemistry, Mary Campbell, Ph.D. and Shawn Farrell, Ph.D. 2005
  11. Regulatory mechanisms of hemoglobin oxygen affinity in acidosis and alkalosis.       J Clin Invest 1971 March; 50(3): 700–706
  12. Hematology in clinical practice: a guide to diagnosis and management Robert S. Hillman, Kenneth A. Ault, Henry M. Rinder 2002
  13. Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect. PLoS One 2009 Sep 15;4(9):e7033
  14. Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma? Biochim Biophys Acta 2011 Jun;1807(6):552-61
  15. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res 2005 Apr 15;65(8):3171-8
  16.  Relationship between oxygen and glucose consumption by transplanted tumors in vivo. Cancer Res 1967 Jun;27(6):1041-52
  17. Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen–caesium chloride.
  18. Food Chem Toxicol 1992 Oct;30(10):865-9
  19. Inhibition of clastogenic effects of cesium chloride in mice in vivo by chlorophyllin. Toxicol Lett 1991 Jun;57(1):11-7
  20. Comparative efficacy of chlorophyllin in reducing cytotoxicity of some heavy metals. Biol Met 1991;4(3):158-61
  21. Modification of cesium toxicity by calcium in mammalian system. Biol Trace Elem Res 1991 Nov;31(2):139-45
  22. Cytogenetic damage induced in vivo to mice by single exposure to cesium chloride. Environ Mol Mutagen 1991;18(2):87-91
  23. Clastogenic effects of cesium chloride on mouse bone marrow cells in vivo. Mutat Res 1990 Aug;244(4):295-8
  24. Cesium toxicity: a case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003 Feb;25(1):114-6
  25. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006 Dec;12(10):1011-4
  26. Acquired long QT syndrome and monomorphic ventricular tachycardia after alternative treatment with cesium chloride for brain cancer. Mayo Clin Proc 2004 Aug;79(8):1065-9
  27. Polymorphic ventricular tachycardia in a woman taking cesium chloride. Pacing Clin Electrophysiol 2001 Apr;24(4 Pt 1):515-7
  28. Life-threatening Torsades de Pointes resulting from “natural” cancer treatment.       Clin Toxicol (Phila) 2009 Jul;47(6):592-4
  29. Torsades de pointes – a report of a case induced by caesium taken as a complementary medicine, and the literature review. J Clin Pharm Ther 2013 Jun;38(3):254-7
  30. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy 2008 Aug;28(8):1059-65
  31. Cesium chloride-induced torsades de pointes. Can J Cardiol 2009 Sep;25(9):e329-31
  32. Cesium chloride induced ventricular arrhythmias in dogs: three-dimensional activation patterns and their relation to the cesium dose applied. Basic Res Cardiol 2000 Apr;95(2):152-62.
  33. Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs: atrial torsades de pointes? J Cardiovasc Electrophysiol 1998 Sep;9(9):970-5
  34. Spontaneous, electrically, and cesium chloride induced arrhythmia and afterdepolarizations in the rapidly paced dog heart. Pacing Clin Electrophysiol 2001 Apr;24(4 Pt 1):474-85
  35. The high pH therapy for cancer tests on mice and humans. Pharmacol Biochem Behav 1984;21 Suppl 1:1-5

Chaparral Safety

Medical journals have reported that the use of the herb chaparral has been linked to cases of hepatitis.  The chaparral issue started a while back when out of the clear blue there were 13 cases of hepatitis reported in a two year period in people taking chaparral supplements. There are several unanswered questions though as to the validity of this claim.

For instance, chaparral has been in use for thousands of years and is still widely used from Mexico to South America to cure various diseases such as cancer.  Yet there have only been 13 isolated cases of hepatitis reported in a two year period.

Furthermore, up to recently the chaparral extract nordihydroguaiaretic acid (NDGA) was widely used in the food industry for its powerful antioxidant properties.  It was added to foods to prevent oils in the foods from becoming rancid.

NDGA is also the active component that inhibits the cellular division of cancer cells and destroys pathogens such as many viruses.

Despite decades of use as a food ingredient there were never any cases of hepatitis reported.  And the FDA never explained why there were only 13 isolated cases supposedly from chaparral in this two year period with no cases reported before, nor since.

By the way, contrary to popular belief, chaparral was never banned from the market.  The FDA called for a voluntary moratorium since they could not legally ban the herb.  The FDA can only ban an herb if they can prove that the herb shows an unreasonable risk to safety, which the FDA could never do with chaparral.  When stores did not comply with their “voluntary moratorium” though, the FDA would harass stores that they found openly selling chaparral despite their actions being a violation of the law.  The reason that the FDA was never able to prove an unreasonable danger was because the FDA left out some very important facts about these 13 patients.  These included the facts that many of these patients were taking pharmaceutical drugs well known for causing liver damage.  Other patients were reported to have preexisting liver failure, BEFORE they started taking the chaparral.
Another fact they left out is the stability of the alkaloids in the plant.  Chaparral does contain pyrrolizidine alkaloids (PAs) when fresh.  Some PAs are harmful to the liver, though they are also relatively unstable.  As an example, both fresh comfrey and dried comfrey have been tested on rats to test for liver toxicity.  What was determined was that only the fresh comfrey caused hepatitis in the rats but not the dried comfrey since the PAs are readily destroyed by oxidation when dried.  The same was found in cattle feeds that contained plants with PAs.   Studies showed the PAs were destroyed in about 20 to 30 days of curing the hay rendering the hay safe.

This brings up another point.  Some herbs have to be processed in a certain way to make them safe and useful.  For instance rehmannia is Chinese foxglove root that is boiled in 9 changes of water to render it safe.  Jack in the Pulpit root has to be aged for two years to prevent caustic burns.  Some anthraquinone laxative herbs must be aged for several years before they can be used.  The point here is that an herb should not be considered dangerous just because it is not prepared right since the herb can be safe if properly prepared.  Chaparral should not be used fresh.  Instead, it should be dried and aged a few months to make sure all the PAs are destroyed before use.

Tag Cloud